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Research suggests that GIP receptor activation contributes significantly to fat metabolism and energy expenditure in ways that GLP-1 alone does not address

It can even lead to neurological problems such as amyotrophic lateral sclerosis (ALS), Parkinsons disease, or Alzheimers disease

One serious problem is considerable inter-individual variability of LTLs which was repeatedly observed in molecular epidemiological studies across multiple populations and which may substantially complicate the interpretation of individual data (Bodelon et al., 2020)

doi: 10.1186/1471-2164-14-669 101 XiaY.WangD.PanX.XiaB.WengY.LongY.et al